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Report via TMZ -- Conor McGregor personally attacked Khabib's wife -- and seemingly mocked Muslim tradition -- tweeting a photo of the UFC champ and his bride ... and calling her a "towel."

McGregor went on a Twitter rampage Tuesday night ... unleashed a fury of Tweets directed at Paulie Malignaggi -- who slapped his good friend, Artem Lobov, earlier in the day -- and Nurmagomedov.

“Don’t be scared of the rematch you little scurrying rat" ... McGregor wrote.

Conor dug in, getting personal ... posting 2 photos from Khabib's wedding day -- along with the caption, "Your wife is a towel mate" -- appearing to make fun of Khabib's wife's clothing.

McGregor deleted the message minutes later.

Khabib and his wife are devout Muslims ... and his manager, Ali Abdelaziz, took the insult as a direct slight at Khabib's religion.

"Talking shit, this guy is insulting someone’s wife and making fun of her religion and belief. He doesn’t realize he’s insulting 1.5 billon Muslims. Religion and family is a no no. You’re fucked Connor, let’s see what the media is going to say now. He’s a rapist, and a bitch."

Conor's used racially and religiously charged rhetoric to sell fights and belittle fighters in the past ... so it's possible this entire incident is an attempt to goad Khabib into a rematch.

**UPDATE** Khabib just fired back at his arch nemesis ... clearly alluding to the reports that McGregor is under investigation for sexual assault in Ireland (Conor's rep bashed the report as a "rumor," but did not address the allegations).

"Rapist, you are Rapist," Nurmagomedov tweeted.

"You are a hypocrite who is not responsible for your actions. Justice will find you. We will see."

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